Key result
Reduced exercise capacity during bicycle stress testing was progressively associated with increased all-cause mortality, reaching HR 8.5 (95% CI 7.2-10.0) for severe reduction versus normal.
Why the study?
A new grading of exercise capacity during bicycle stress testing based on the Kalmar reference material had been proposed in Sweden but not yet validated.
Does reduced exercise capacity graded by new recommendations predict mortality and cardiovascular hospitalizations in patients undergoing bicycle stress testing?
Cohort (n=13,887)
No
Does reduced exercise capacity graded by new recommendations predict mortality and cardiovascular hospitalizations in patients undergoing bicycle stress testing?
Effect estimate: HR 8.5 (95% CI 7.2-10.0)
A new grading system for exercise capacity during bicycle stress testing provides significant prognostic information, with progressively worse mortality and cardiovascular outcomes as exercise capacity declines.
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May aid risk stratification during bicycle stress testing; extends observational evidence but leaves causality and interventions open.
Lindow et al. (2019) conducted a cohort in Patients undergoing bicycle exercise stress testing (n=13,887). Reduced exercise capacity vs. Normal exercise capacity (75 to <120% of predicted) was evaluated on All-cause mortality (HR 8.5, 95% CI 7.2-10.0). Reduced exercise capacity during bicycle stress testing was progressively associated with increased all-cause mortality, reaching HR 8.5 (95% CI 7.2-10.0) for severe reduction versus normal.
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