Key result
Pulmonary hypertension is associated with abnormal right ventricular early relaxation and increased filling pressures, suggesting diastolic dysfunction precedes systolic dysfunction.
Why the study?
Is pulmonary hypertension associated with abnormal right ventricular early relaxation as measured by invasive pressure measurement?
Observational (n=25)
Is pulmonary hypertension associated with abnormal right ventricular early relaxation as measured by invasive pressure measurement?
Invasive hemodynamic measurements demonstrate that right ventricular early relaxation is abnormal in patients with pulmonary hypertension, suggesting that RV diastolic dysfunction may precede systolic dysfunction.
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Supports early RV diastolic evaluation in PH; hypothesis-generating without prospective validation.
Murch et al. (2015) conducted an observational in Pulmonary hypertension (n=25). Pulmonary hypertension vs. Non-pulmonary hypertension was evaluated on Right ventricular early relaxation (RV τ) and filling pressures. Pulmonary hypertension is associated with abnormal right ventricular early relaxation and increased filling pressures, suggesting diastolic dysfunction precedes systolic dysfunction.
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