Key result
OSAHS complicating cerebral infarction links to higher inflammatory markers and homocysteine versus infarction alone.
Why the study?
The study was conducted to investigate the associations of obstructive sleep apnea hypopnea syndrome complicated by cerebral infarction with intestinal flora, inflammatory factors, homocysteine, and adiponectin expression.
Are there differences in intestinal flora, inflammatory factors, homocysteine, and adiponectin expression among patients with OSAHS complicated by cerebral infarction, simple cerebral infarction, and healthy controls?
Observational (n=86)
Are there differences in intestinal flora, inflammatory factors, homocysteine, and adiponectin expression among patients with OSAHS complicated by cerebral infarction, simple cerebral infarction, and healthy controls?
OSAHS complicated by cerebral infarction is associated with a more severe inflammatory profile, higher homocysteine, lower adiponectin, and distinct intestinal flora compared to simple cerebral infarction.
Answers are grounded in this paper and cite their sources.
Indicates heightened inflammation in OSAHS-stroke overlap; leaves open whether targeting these markers improves outcomes.
OBJECTIVE: The aim of this study was to investigate the associations between obstructive sleep apnea hypopnea syndrome (OSAHS) complicated by cerebral infarction and intestinal flora, inflammatory factors, homocysteine, and adiponectin expression. PATIENTS AND METHODS: A total of 30 healthy volunteers (control group), 28 patients with simple cerebral infarction (cerebral infarction group) and 28 patients with OSAHS complicated by cerebral infarction (OSAHS + cerebral infarction group) were enrolled as research objects. The fecal bacterial DNA of research objects was extracted and subject to 16S ribosomal ribonucleic acid sequencing. Furthermore, the levels of inflammatory factors, homocysteine and adiponectin in the peripheral blood were detected. RESULTS: Compared with control group, cerebral infarction group exhibited significantly higher levels of interleukin-4 (IL-4), tumor necrosis factor-beta (TNF-β), IL-1β and C-reactive protein (CRP) (p<0.05). However, the levels of TNF-β, IL-1β and CRP in OSAHS + cerebral infarction group were notably higher than those in cerebral infarction group (p<0.05). The levels of myeloperoxidase (MPO) and malondialdehyde (MDA) were remarkably higher in cerebral infarction group than those in the control group (p<0.05). However, they were significantly higher in OSAHS + cerebral infarction group than cerebral infarction group (p<0.05). Compared with control group, cerebral infarction group exerted a noticeably higher level of homocysteine (p<0.05). However, homocysteine level was markedly higher in OSAHS + cerebral infarction group than that in cerebral infarction group (p<0.05). Adiponectin level was significantly lower in cerebral infarction group than that in the control group (p<0.05). Meanwhile, it was evidently lower in OSAHS + cerebral infarction group than that in the cerebral infarction group (p<0.05). Control group had the highest abundance of Actinobacteria, and cerebral infarction group exhibited the highest abundance of Coriobacteriales, Vagococcus, Sphingobacteriales and Adlercreutzia. However, OSAHS + cerebral infarction group exhibited the highest abundance of Bifidobacterium, Parascardovia, Metascardovia and Anaerostipes caccae. There was a strong positive correlation between Proteobacterium and Ruminococcus (r=0.9, p=0.000) and between Firmicutes and Bacteroidetes (r=0.72, p=0.004). However, there was a significant negative correlation between Firmicutes and Enterobacteriales (r=-0.45, p=0.009). CONCLUSIONS: OSAHS complicated by cerebral infarction is significantly associated with intestinal flora, inflammatory factors, homocysteine and adiponectin expression.
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Zhang et al. (2020) conducted an observational in OSAHS complicated by cerebral infarction (n=86). OSAHS complicated by cerebral infarction vs. Simple cerebral infarction and healthy volunteers was evaluated on Levels of inflammatory factors, homocysteine, adiponectin, and intestinal flora composition (p=<0.05). OSAHS complicated by cerebral infarction was associated with significantly higher levels of TNF-β, IL-1β, CRP, and homocysteine, and lower adiponectin compared to simple cerebral infarction (p<0.05).
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