Key result
Duodenal-jejunal bypass significantly improved oral glucose tolerance in diabetic rats compared with controls (P<0.001), demonstrating that bypassing the proximal intestine ameliorates type 2 diabetes.
Why the study?
Does bypassing the proximal intestine improve glucose tolerance in type 2 diabetic rats?
Population
Goto-Kakizaki (GK) type 2 diabetic rats
Comparison
Duodenal-jejunal bypass or gastrojejunostomy… vs Pair-fed (PF) sham-operated and untreated GK rats
Design
Preclinical
Authors
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Bypassing proximal intestine improves glucose tolerance in diabetic rats; leaves open translation to human type 2 diabetes pending clinical trials.
Does bypassing the proximal intestine improve glucose tolerance in type 2 diabetic rats?
p-value: p=<0.001
Bypassing a short segment of proximal intestine directly ameliorates type 2 diabetes independently of weight loss or malabsorption, suggesting a role of the proximal bowel in T2D pathophysiology.
Rubino et al. (2006) studied Type 2 diabetes. Duodenal-jejunal bypass (DJB) vs. Gastrojejunostomy (GJ), pair-fed sham-operated, and untreated controls was evaluated on Oral glucose tolerance (peak and area-under-the-curve glucose values) (p=<0.001). Duodenal-jejunal bypass significantly improved oral glucose tolerance in diabetic rats compared with controls (P<0.001), demonstrating that bypassing the proximal intestine ameliorates type 2 diabetes.
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