Key result
Blocking MCT1 attenuates hypertensive cardiac remodeling by disrupting the fibroblast-to-cardiomyocyte lactate shuttle.
Why the study?
The underlying mechanisms governing the generation and delivery of lactate from cardiac fibroblasts to cardiomyocytes remained unexplored.
Interrupting the fibroblast-to-cardiomyocyte lactate shuttle via GCN5L1 ablation or MCT1 knockout attenuates hypertensive cardiac remodeling in mice.
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Hypothesis-generating for MCT1 blockade in hypertensive remodeling; requires human validation before any clinical consideration.
Wei et al. (2023) studied Hypertensive cardiac remodeling. GCN5L1 knockout or MCT1 knockout vs. Wild-type mice was evaluated on Cardiac hypertrophy and fibrosis. GCN5L1-MPC2 signaling alters metabolic patterns during Ang II-induced cardiac fibroblast differentiation, and blocking MCT1 disrupts the fibroblast-to-cardiomyocyte lactate shuttle, attenuating cardiac remodeling in hypertension.
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