Key result
Culturing neonatal heart cells on an oriented type I collagen matrix induced an in vivo-like phenotype with parallel myofibrils, mediated by the cardiac alpha 1 beta 1 integrin complex.
Population
Neonatal heart cells (NHCs) in primary culture
Comparison
Culture on a thin film of type I collagen with a… vs Altered tertiary structure of the matrix or…
Design
Preclinical
Follow-up
up to 4 weeks
Authors
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Hypothesis-generating for ECM-integrin effects on myocyte phenotype in vitro; leaves open in vivo or therapeutic translation.
The composition and orientation of the extracellular matrix modulate cardiac myocyte phenotype in vitro via the cardiac alpha 1 beta 1 integrin complex.
Simpson et al. (1994) studied In vitro neonatal heart cells. Oriented thin film of type I collagen (T1C) vs. Altered tertiary structure or blocked integrins was evaluated on Cellular phenotype and myofibril organization. Culturing neonatal heart cells on an oriented type I collagen matrix induced an in vivo-like phenotype with parallel myofibrils, mediated by the cardiac alpha 1 beta 1 integrin complex.
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