What question did this study set out to answer?

To assess the prevalence and anatomical distribution of advanced colorectal neoplasia in asymptomatic women and determine the diagnostic yield of flexible sigmoidoscopy compared with full colonoscopy.

May 18, 2005New England Journal of MedicineOpen Access

Colonoscopic Screening of Average-Risk Women for Colorectal Neoplasia

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To assess the prevalence and anatomical distribution of advanced colorectal neoplasia in asymptomatic women and determine the diagnostic yield of flexible sigmoidoscopy compared with full colonoscopy.
Offered screening colonoscopy to consecutive asymptomatic women referred for colon-cancer screening (N=1463 completed examinations).
Calculated the diagnostic yield of flexible sigmoidoscopy by identifying lesions located in the distal colon or proximal lesions accompanied by concurrent distal index adenomas.
Compared diagnostic detection rates with historical data from age-matched men and women with negative fecal occult-blood tests and no family history of colon cancer.
Advanced colorectal neoplasia was identified in 4.9% of women (72 of 1463) via complete colonoscopy.
Flexible sigmoidoscopy alone would have detected advanced neoplasia in 1.7% of women (25 of 1463) and failed to identify lesions in 3.2% (47 of 1463).
Only 35.2% of women with advanced neoplasia would have had their lesions detected by flexible sigmoidoscopy alone, compared with 66.3% of matched men (P<0.001).

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Implication

Screening cohort study reveals flexible sigmoidoscopy misses most advanced neoplasias in average-risk women, suggesting colonoscopy is the superior screening tool.

Cite This Study

Schoenfeld et al. (2005) studied this question.

synapsesocial.com/papers/6a1247b0c031bb6829a63e56 https://doi.org/10.1056/nejmoa042990

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Implication

Screening cohort study reveals flexible sigmoidoscopy misses most advanced neoplasias in average-risk women, suggesting colonoscopy is the superior screening tool.

Colonoscopic Screening of Average-Risk Women for Colorectal Neoplasia

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Discussion

Implication

Cite This Study

Colonoscopic Screening of Average-Risk Women for Colorectal Neoplasia

Key Points

Discussion

Implication

Cite This Study

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