Why the study?
Obstructive sleep apnea promotes atrial remodeling and fibrosis, but the pathophysiological mechanisms of atrial fibrillation associated with it in cardiac surgery patients required investigation.
Does obstructive sleep apnea increase the risk of postoperative atrial fibrillation and alter atrial remodeling biomarkers in patients undergoing cardiac surgery?
Comparison
Patients with OSA vs non-OSA
Design
Prospective hypothesis-generating pilot cohort study
Key result
Obstructive sleep apnea in cardiac surgery patients increased the risk of postoperative atrial fibrillation compared to non-OSA patients (46.7% vs. 19.5%; OR 3.61, 95% CI 1.01-12.92; p=0.042).
Authors
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OSA was associated with higher POAF risk after cardiac surgery; leaves open whether screening or treatment modifies outcomes.
Cohort (n=56)
Does obstructive sleep apnea increase the risk of postoperative atrial fibrillation and alter atrial remodeling biomarkers in patients undergoing cardiac surgery?
Effect estimate: OR 3.61 (95% CI 1.01-12.92)
Absolute Event Rate: 46.7% vs 19.5%
p-value: p=0.042
Obstructive sleep apnea is associated with an increased risk of postoperative atrial fibrillation, likely driven by dysregulated inflammation, fibrosis, and altered miRNA expression.
López‐Gálvez et al. (2023) conducted a cohort in Obstructive sleep apnea and postoperative atrial fibrillation (n=56). Obstructive sleep apnea (OSA) vs. Non-OSA was evaluated on Postoperative atrial fibrillation (POAF) (OR 3.61, 95% CI 1.01-12.92, p=0.042). Obstructive sleep apnea in cardiac surgery patients increased the risk of postoperative atrial fibrillation compared to non-OSA patients (46.7% vs. 19.5%; OR 3.61, 95% CI 1.01-12.92; p=0.042).