Screening family members of sudden unexplained death victims is recommended, as inherited conditions may affect up to 40% of these families.
May aid genetic screening in sudden death families; leaves open prospective clinical validation of this NGS panel.
Sudden unexplained death due to cardiac arrest refers to a group of heterogeneous heart disorders characterized by sudden cessation of cardiac activity followed by hemodynamic collapse. It may be associated with structural heart disease or may occur in the absence of structural abnormalities. These inherited conditions increase the risk of sudden unexplained death in living relatives when there is a family history of sudden death. It is recommended to screen other family members of sudden unexplained death victims, as studies have revealed affected individuals in 40% of families.
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Precone et al. (2019) conducted a review in Sudden unexplained death due to cardiac arrest. Next-generation sequencing (NGS) panel was evaluated.
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