Key result
Thrombolytic therapy for acute myocardial infarction improves left ventricular function, with end-systolic volume at 90 or 180 minutes correlating with early TIMI flow grades and survival.
Why the study?
Does thrombolytic therapy improve left ventricular function and survival in patients with acute myocardial infarction?
Does thrombolytic therapy improve left ventricular function and survival in patients with acute myocardial infarction?
Following thrombolytic therapy for acute MI, left ventricular function (specifically end-systolic volume) remains a critical prognostic factor correlating with survival.
End-systolic volume assessment aids post-thrombolysis prognostication in acute MI; reinforces LV function as key survival correlate in research.
The introduction of thrombolytic therapy to treat eligible patients with acute infarction has markedly reduced deaths from left ventricular (LV) failure. Following reperfusion therapy for acute myocardial infarction (MI), LV function remains the single most significant prognostic factor. Three trials have shown that LV function and survival improved in concert, following randomization to receive thrombolytic therapy. The Global Utilization of Strategies to Open Occluded Coronary Arteries study (GUSTO‐1) showed that end‐systolic volume at 90 minutes (or 180 minutes) after starting thrombolytic therapy correlates with early thrombolysis in myocardial infarction (TIMI) flow grades as well as survival.
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French et al. (1998) conducted a review in Acute myocardial infarction. Thrombolytic therapy was evaluated. Thrombolytic therapy for acute myocardial infarction improves left ventricular function, with end-systolic volume at 90 or 180 minutes correlating with early TIMI flow grades and survival.
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