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November 21, 2016BMC Infectious DiseasesOpen Access

Age patterns and transmission characteristics of hand, foot and mouth disease in China

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Key result

The basic reproduction number of HFMD in China ranged from 15.8 to 30, with the highest infection risk among children aged 3-5 years in most provinces and 10-14 years in Tibet.

Population

Hand, foot and mouth disease (HFMD) cases across 31 provinces in mainland China from 2008 to 2012

Design

Other

Authors

JZJijun ZhaoFJFachun JiangLZLianfa Zhong

Discussion

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Overview

Geographic HFMD age-risk variation supports tailored prevention; leaves open prospective validation before practice change.

Study Design

Type

Observational

Structured PICO

P
Population
Hand, foot and mouth disease (HFMD) cases across 31 provinces in mainland China from 2008 to 2012
O
Outcome
Age-specific transmission characteristics and reporting rates of HFMD

HFMD transmission characteristics and age-specific incidence vary geographically in China, suggesting that control measures should be targeted to specific age groups depending on the region.

Limitations

  • Assumed that reporting rates were constant with respect to age, which may underestimate the force of infection in adults.
  • Assumed that the population is constant with age.
  • Did not explore which social or climatic factors caused the variation in HFMD transmission.
  • Estimates of the basic reproduction number (R0) were crude and not based on age-specific contact matrices.

Cite This Study

Zhao et al. (2016) conducted an observational in Hand, foot and mouth disease (HFMD). The basic reproduction number of HFMD in China ranged from 15.8 to 30, with the highest infection risk among children aged 3-5 years in most provinces and 10-14 years in Tibet.

synapsesocial.com/papers/6a125758bb918b6e5b671c6ahttps://doi.org/10.1186/s12879-016-2008-y
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Also Consider

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  1. 1Epidemiological Analysis, Detection, and Comparison of Space-Time Patterns of Beijing Hand-Foot-Mouth Disease (2008–2012)2014 · 75 citations
  2. 2Spatiotemporal Dynamics of Hand-Foot-Mouth Disease and Its Relationship with Meteorological Factors in Jiangsu Province, China2015 · 76 citations
  3. 3Hand, foot and mouth disease: spatiotemporal transmission and climate2011 · 137 citations
  4. 4Determinants of the Incidence of Hand, Foot and Mouth Disease in China Using Geographically Weighted Regression Models2012 · 148 citations
  5. 5Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou, China2013 · 148 citations