Why the study?
The safety and efficacy of TAVR compared with SAVR had yet to be comprehensively assessed in intermediate- and low-risk patients with severe symptomatic aortic stenosis.
Does transcatheter aortic valve replacement improve mortality, stroke, and length of stay compared to surgical aortic valve replacement in intermediate and low-risk patients with severe symptomatic aortic stenosis?
Population
8884 intermediate- and low-risk severe symptomatic aortic stenosis patients across 9 studies
Comparison
TAVR vs SAVR
Design
Systematic review of randomized controlled trials
Key result
TAVR demonstrated significantly lower all-cause mortality and stroke incidence at 30 days and 1 year compared to SAVR in a systematic review of 8884 patients.
Authors
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Supports TAVR preference in intermediate/low-risk aortic stenosis; extends RCT evidence with pooled data from 8884 patients.
Systematic Review (n=8,884)
Does transcatheter aortic valve replacement improve mortality, stroke, and length of stay compared to surgical aortic valve replacement in intermediate and low-risk patients with severe symptomatic aortic stenosis?
TAVR demonstrates superior short-term survival, lower stroke risk, and shorter hospital stays compared to SAVR in intermediate and low-risk patients with severe symptomatic aortic stenosis.
Hamodat et al. (2024) conducted a systematic review in severe symptomatic aortic stenosis (n=8,884). Transcatheter aortic valve replacement (TAVR) vs. Surgical aortic valve replacement (SAVR) was evaluated on Mortality, stroke, length of stay, and other perioperative outcomes. TAVR demonstrated significantly lower all-cause mortality and stroke incidence at 30 days and 1 year compared to SAVR in a systematic review of 8884 patients.
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