What question did this study set out to answer?

To review the molecular mechanisms by which bacterial protein toxins manipulate eukaryotic Rho GTPases to alter cellular signaling and the actin cytoskeleton.

July 1, 2000FEMS Microbiology LettersOpen Access

Bacterial protein toxins targeting Rho GTPases

View Full Paper

Ask AI

Bookmark

Authors

MLMaria LermLinköping University GSGudula SchmidtUniversity of Freiburg KAKlaus AktoriesNorthwestern University

Discussion

Member takes

Implication

Scientific review demonstrates how bacterial toxins activate or inhibit Rho GTPases in eukaryotic cells, highlighting diverse enzymatic and mimicry mechanisms.

Key Points

To review the molecular mechanisms by which bacterial protein toxins manipulate eukaryotic Rho GTPases to alter cellular signaling and the actin cytoskeleton.
Synthesized molecular evidence on covalent modifications and regulatory mimicry utilized by bacterial toxins targeting host Rho GTPases.
Evaluated differences between secreted toxins and effector proteins injected via the bacterial type-III secretion system.
Bacterial toxins covalently modify Rho GTPases to either inhibit activity via ADP-ribosylation and glucosylation or stimulate activity through deamidation and transglutamination.
Injected type-III secretion toxins alter the regulatory GTPase cycle non-covalently by mimicking endogenous GTPase-activating proteins or guanine nucleotide exchange factors.

Cite This Study

Lerm et al. (2000) studied this question.

synapsesocial.com/papers/6a125a3ef7bd4f5c7da629bb https://doi.org/10.1111/j.1574-6968.2000.tb09159.x

View Full Paper

Ask AI

Bookmark

Implication

Scientific review demonstrates how bacterial toxins activate or inhibit Rho GTPases in eukaryotic cells, highlighting diverse enzymatic and mimicry mechanisms.

Bacterial protein toxins targeting Rho GTPases

Discussion

Member takes

Implication

Key Points

Cite This Study

Bacterial protein toxins targeting Rho GTPases

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider