What question did this study set out to answer?

To compare the diagnostic performance, completion speed, and demographic fairness of the Digital Clock and Recall assessment against the Mini-Mental State Examination for identifying mild cognitive impairment and mild dementia.

January 2, 2024Alzheimer s Research & TherapyOpen Access

Digital Clock and Recall is superior to the Mini-Mental State Examination for the detection of mild cognitive impairment and mild dementia

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To compare the diagnostic performance, completion speed, and demographic fairness of the Digital Clock and Recall assessment against the Mini-Mental State Examination for identifying mild cognitive impairment and mild dementia.
Multicenter interventional trial (Bio-Hermes study, ClinicalTrials.gov NCT04733989) analyzing 706 participants (mean age 71.5 ± 6.7 years; 58.9% female; 15.4 ± 2.7 years of education) classified as cognitively unimpaired (n=360), mild cognitive impairment (n=234), or probable mild Alzheimer's dementia (n=111).
Evaluated diagnostic classification accuracy of DCR and MMSE against composite cohorts defined by the Rey Auditory Verbal Learning Test (RAVLT), Trail Making Test-Part B (TMT-B), and Functional Activities Questionnaire (FAQ), while evaluating score differences across race, ethnicity, and education.
The DCR was superior to the MMSE in discriminating mild cognitive impairment and early dementia, yielding an AUC of 0.70 compared to 0.63 for the MMSE.
DCR administration was completed in under 3 minutes across all ages and cognitive statuses, and successfully identified impairment in 84 of 104 individuals (80.7%) misclassified as unimpaired by the MMSE (score ≥ 28) despite confirmed verbal memory deficits on the RAVLT.
DCR scores showed no significant difference between Hispanic and non-Hispanic participants, demonstrating significantly less ethnic bias than the MMSE.

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Implication

Randomized trial demonstrates superior detection of mild cognitive impairment using digital clock and recall in older adults, highlighting its efficiency and lower ethnic bias for primary care.

Cite This Study

Jannati et al. (2024) studied this question.

synapsesocial.com/papers/6a125f84a4bed3c7b1670271 https://doi.org/10.1186/s13195-023-01367-7

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Implication

Randomized trial demonstrates superior detection of mild cognitive impairment using digital clock and recall in older adults, highlighting its efficiency and lower ethnic bias for primary care.

Digital Clock and Recall is superior to the Mini-Mental State Examination for the detection of mild cognitive impairment and mild dementia

Key Points

Discussion

Implication

Cite This Study

Digital Clock and Recall is superior to the Mini-Mental State Examination for the detection of mild cognitive impairment and mild dementia

Key Points

Discussion

Implication

Cite This Study

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