Key result
Conservative management alone resolves a massive 1200 mg rivaroxaban overdose in normal renal function.
Why the study?
Does conservative management suffice for acute massive rivaroxaban overdose in patients with normal renal function and no bleeding?
Case Report (n=1)
No
Does conservative management suffice for acute massive rivaroxaban overdose in patients with normal renal function and no bleeding?
Conservative management may be sufficient for acute massive rivaroxaban overdose in patients with normal renal function and no active bleeding.
Supports conservative management in select massive rivaroxaban overdoses; hypothesis-generating and requires prospective confirmation.
In the cases of acute rivaroxaban overdose, conservative management without prothrombin complex concentrate or other coagulation factors may be sufficient if renal function is normal and there is no bleeding.
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Ghodsi et al. (2021) conducted a case report in Rivaroxaban overdose (n=1). Conservative management was evaluated on Normalization of coagulation parameters and absence of bleeding. Conservative management without prothrombin complex concentrate or other coagulation factors was sufficient to treat a massive 1200 mg rivaroxaban overdose in a patient with normal renal function.
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