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Cross-sectional study finds high rates of matching tympanic membrane retractions in contralateral ears of cholesteatoma patients, indicating retractions drive early disease pathogenesis.
Objective . To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE. Methods . Videotoscopy of both ears in 432 patients with cholesteatomas classified as posterior epitympanic (PEC), posterior mesotympanic (PMC), two routes, or undetermined. Tympanic membrane (TM) retractions were classified by location and severity and TM perforations according to signs of previous TM retraction. Results . TM retraction was the most prevalent alteration in the CLE (42.6%). Cholesteatoma was observed in 17.4%. In patients with PEC, the retraction in the CLE was more frequent in the PF (66.7%) than in the PT (1.4%), and in those with two-route cholesteatoma, the retraction in the CLE most frequently involved both the PT and PF (65.6%;p<0.0001). Conclusion . Our results confirm the essential role of TM retraction at least in the earlier phases of cholesteatoma pathogenesis.
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Rosito et al. (2018) studied this question.
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