Key result
Quadruple single pill combination undergoes testing against valsartan/hydrochlorothiazide for 24-hour ambulatory systolic BP.
Why the study?
Does compound reserpine and triamterene tablets improve 24-hour ambulatory systolic BP in patients with primary mild-to-moderate hypertension compared to valsartan/hydrochlorothiazide?
RCT (n=1,332)
1:1
Does compound reserpine and triamterene tablets improve 24-hour ambulatory systolic BP in patients with primary mild-to-moderate hypertension compared to valsartan/hydrochlorothiazide?
This study protocol outlines a randomized controlled trial to evaluate the efficacy of a quadruple single-pill combination versus valsartan/hydrochlorothiazide for blood pressure control in mild-to-moderate hypertension.
Does not yet alter hypertension management; leaves open whether quadruple SPC outperforms valsartan/HCTZ on ambulatory SBP.
INTRODUCTION: Hypertension constitutes the primary health burden of cardiovascular diseases, and the global control of blood pressure (BP) remains insufficient. Single pill combinations (SPCs) are employed as a means to streamline the management of poor BP control due to non-adherence and treatment inertia. The compound reserpine and triamterene tablets constitute a quadruple SPC, comprising reserpine 0.1 mg, dihydralazine 12.5 mg, hydrochlorothiazide 12.5 mg and triamterene 12.5 mg. It is widely employed in primary medical institutions and has favourable efficacy, tolerability and cost-effectiveness. METHODS AND ANALYSIS: The COSPQ-BP trial is a 12-week prospective randomised controlled trial to enrol 1332 patients with primary mild-to-moderate hypertension. Participants who meet the inclusion criteria will be randomly assigned to a 1:1 ratio to an intervention group (compound reserpine and triamterene tablets) or a control group (valsartan/hydrochlorothiazide). The primary outcome will be mean changes from baseline in 24-hour ambulatory systolic BP after intervention for 12 weeks. The secondary outcomes have been predetermined and will primarily encompass the following: (1) changes in other BP measures, as well as changes in blood lipids, blood glucose and uric acid at 12 weeks and (2) evaluation of the impact of starting antihypertensive therapy with compound reserpine and triamterene tablets or valsartan/hydrochlorothiazide on the depressive and anxiety statess of patients. ETHICS AND DISSEMINATION: The study protocol (version number: V5.0, version date: 17 January 2023) has been approved by the ethics committee (Biomedical Ethics Committee of West China Hospital of Sichuan University, approval number: Review (51) in 2023). Written informed consent will be obtained from each participant by researchers. The findings of this study will be disseminated through conference presentations and peer-reviewed publications. TRIAL REGISTRATION: This study was registered at the Chinese Clinical Trials Registry (ChiCTR2300067920). The COSPQ-BP trial is currently enrolling. The study period will be from 1 January 2024 to 31 December 2025.
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Jia et al. (2025) conducted an RCT in primary mild-to-moderate hypertension (n=1,332). compound reserpine and triamterene tablets vs. valsartan/hydrochlorothiazide was evaluated on mean changes from baseline in 24-hour ambulatory systolic BP after intervention for 12 weeks. A quadruple single pill combination will be compared to valsartan/hydrochlorothiazide in 1332 randomized patients to evaluate changes in 24-hour ambulatory systolic blood pressure.
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