What is the clinical evidence from this study?

Study design: Observational. Population: First-ever stroke (n=4614). Intervention: Female sex vs. Male sex. Primary outcome: Stroke incidence rate (per 100,000/y) (IRR 0.68, p=<0.001).

What does this research mean for the field?

Overall stroke incidence is significantly lower in women than in men, and this sex gap remained stable from 1987 to 2012, except for subarachnoid hemorrhage. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate temporal trends in stroke incidence between men and women and determine whether changes in vascular risk factor distribution have altered sex differences over time.

March 9, 2017Stroke

Temporal Trends in Sex Differences With Regard to Stroke Incidence

Q: What are the key findings of this study?

Overall stroke incidence was significantly lower in women than in men (112 vs 166 per 100,000/y; IRR 0.68; P<0.001), and this sex gap remained stable from 1987 to 2012.

Q: What does this research mean for the field?

Overall stroke incidence is significantly lower in women than in men, and this sex gap remained stable from 1987 to 2012, except for subarachnoid hemorrhage. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate temporal trends in stroke incidence between men and women and determine whether changes in vascular risk factor distribution have altered sex differences over time.

View Full Paper

Ask AI

Bookmark

Key result

Overall stroke incidence was significantly lower in women than in men (112 vs 166 per 100,000/y; IRR 0.68; P<0.001), and this sex gap remained stable from 1987 to 2012.

Population

4,614 patients with first-ever stroke between 1987 and 2012 from a population-based registry in Dijon…

Design

Cohort

Follow-up

1987 to 2012

Authors

MGM GiroudUniversité de Bourgogne BDBenoît DelpontUniversity of Reunion Island BDBenoît DaubailCHU Dijon Bourgogne

Discussion

Member takes

Implication

Stable sex gap in stroke incidence warrants no practice change; leaves open sex-specific prevention trials in aging populations.

Key Points

To evaluate temporal trends in stroke incidence between men and women and determine whether changes in vascular risk factor distribution have altered sex differences over time.
Identified N=4,614 patients (53.1% women) with first-ever ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, or undetermined stroke between 1987 and 2012 in Dijon, France.
Calculated incidence rates stratified by age, sex, and stroke subtype, using Poisson regression to estimate incidence rate ratios (IRRs) across 5-year intervals.
Overall stroke incidence was significantly lower in women than men (112 vs 166 per 100,000/year; IRR, 0.68; P < 0.001), remaining stable over time with period-specific IRRs ranging from 0.63 to 0.72.
Ischemic stroke incidence increased slightly in both men (IRR, 1.011; 95% CI, 1.005–1.016; P = 0.001) and women (IRR, 1.013; 95% CI, 1.007–1.018; P = 0.001), while sex disparities remained unchanged for ischemic and intracerebral stroke.
The lower incidence of subarachnoid hemorrhage initially observed in women vanished over the 25-year observation period due to a steady rise in female cases.

Study Design

Type

Observational (n=4,614)

Multicenter

Structured PICO

Population

4,614 patients with first-ever stroke (ischemic, spontaneous intracerebral hemorrhage, subarachnoid hemorrhage, and undetermined stroke) between 1987 and 2012 from a population-based registry in Dijon, France. 53.1% women.

Outcome

Stroke incidence rates (overall and by subtype) and temporal trendshard clinical

Main Result

Effect estimate: IRR 0.68

Absolute Event Rate: 112% vs 166%

p-value: p=<0.001

The lower incidence of stroke in women compared to men remained stable over a 25-year period, though more women experience incident strokes annually due to longer life expectancy.

Cite This Study

Giroud et al. (2017) conducted an observational in First-ever stroke (n=4,614). Female sex vs. Male sex was evaluated on Stroke incidence rate (per 100,000/y) (IRR 0.68, p=<0.001). Overall stroke incidence was significantly lower in women than in men (112 vs 166 per 100,000/y; IRR 0.68; P<0.001), and this sex gap remained stable from 1987 to 2012.

synapsesocial.com/papers/6a1275abea48cb855a34e29e https://doi.org/10.1161/strokeaha.116.015913

View Full Paper

Ask AI

Bookmark

Temporal Trends in Sex Differences With Regard to Stroke Incidence

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Temporal Trends in Sex Differences With Regard to Stroke Incidence

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider