Key result
In Scottish adults, being in the lowest quintile of physical health-related quality of life was a strong independent predictor of all-cause death (HR 2.81) compared to the highest quintile.
Why the study?
Does lower physical and mental health-related quality of life predict incident cancer, coronary heart disease, and mortality in the general population?
Cohort (n=5,272)
Does lower physical and mental health-related quality of life predict incident cancer, coronary heart disease, and mortality in the general population?
Lower physical health-related quality of life is an independent predictor of all-cause mortality, incident cancer, and coronary heart disease in the general population.
Answers are grounded in this paper and cite their sources.
Lowest physical HRQoL quintile associated with higher mortality; leaves open utility for risk stratification or cancer/CHD prediction.
BACKGROUND: Health-related quality of life (HRQoL) is associated with adverse outcomes in disease-specific populations. This study examines whether it is also independent predictor of incident cancer, coronary heart disease (CHD) and mortality in the general population. METHODS: The records of adult participants in the Scottish Health Survey 2003 were linked with hospital admissions, cancer registrations and death certificates. Cox proportional hazard models were used to explore the associations between quintiles of physical and mental component summary score (PCS and MCS respectively) of the SF-12 and adverse outcomes. Higher quintiles of both PCS and MCS indicate better health status. RESULTS: Among the 5,272 study participants, the mean PCS score was 49 (standard deviation (SD) 10.3). Participants were followed-up for a mean of 7.6 years. On survival analysis the lowest quintile of PCS was a strong predictor of all-cause death (hazard ratio (HR) 2.81, 95% CI 1.76, 4.49), incident cancer (HR 1.63, 95% CI 1.10, 2.42), and CHD events (HR 1.99, 95% CI 1.00, 3.96), compared to the highest quintile. This association was independent of adiposity and other confounders. The mean MCS score 52 (SD 8.8). MCS quintile was not associated with incident cancer and CHD, and the association between MCS and all-cause death (HR 1.33, 95% CI 1.01, 1.75) became non-significant after adjustment for adiposity. CONCLUSION: Physical HRQoL is a significant predictor of a range of adverse outcomes, even after adjustment for adiposity and other confounders. This study highlights the importance of perceived health in the general population.
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Haq et al. (2014) conducted a cohort in General population (n=5,272). Lowest quintile of physical component summary (PCS) score vs. Highest quintile of PCS score was evaluated on All-cause death (HR 2.81, 95% CI 1.76, 4.49, p=<0.001). In Scottish adults, being in the lowest quintile of physical health-related quality of life was a strong independent predictor of all-cause death (HR 2.81) compared to the highest quintile.
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