An efficient approach for the total synthesis of sumalactone A

Sumalactone A, a 10-membered Benzannulated macrolactone, was synthesised in a straightforward and efficient stereoselective manner using affordable and readily accessible starting materials. The main steps in this convergent synthesis are Vilsmeier-Haack formylation, Grignard reaction, alkylation of 1,3-dithiane and Yamaguchi macrolactonization.