Key result
A flexible self-calculation scoring model predicts stroke occurrence with ~91% accuracy.
Why the study?
Identifying and managing determinants of stroke across various datasets are essential for primary prevention, but flexible scoring models adaptable to different datasets were needed.
Can a flexible self-calculation scoring model accurately determine the risk of stroke occurrence based on clinical variables?
Observational (n=41,931)
Can a flexible self-calculation scoring model accurately determine the risk of stroke occurrence based on clinical variables?
A simple, flexible scoring model based on four clinical variables (age, glucose, heart disease, hypertension) can help individuals self-calculate stroke risk for primary prevention.
Answers are grounded in this paper and cite their sources.
May support self-calculation of stroke risk; hypothesis-generating and requires prospective validation.
Stroke has become a significant threat to global public health, the ideal solution to which is primary prevention. Identification and management of determinants of stroke among various variables in different datasets are essential steps for its primary prevention. This study aimed to develop a flexible scoring model, which can easily modify different datasets. The public dataset containing 41,931 cases with 643 occurrences of stroke was randomly divided into training, validation, and test datasets comprising 25,158 (60%), 8,386 (20%), and 8,387 (20%) cases, respectively. Three continuous variables (age, body mass index, and average glucose level) and seven categorical variables (heart disease, hypertension, sex, married/smoking/work/residence status) in the dataset were converted using the weight of evidence method. The significant variables among 10 transformed variables were selected using multivariable logistic regression analyses. The scoring model for stroke occurrence was developed in the training and validation datasets, and performance was evaluated in the test dataset. Age, average glucose level, heart disease, and hypertension were significant variables of stroke occurrence. The scoring model was easily calculated using four determinants and indicates that the stroke occurrence ranged from 0.04 to 12.50%. The performance of the scoring model on the test dataset was similar to that on the validation dataset. This novel point scoring model is flexible enough to modify various datasets and can be used for determinant identification. Furthermore, its simplicity allows individuals to manage determinants by self-calculating stroke occurrence. Our model contributes to primary prevention using determinant identification and management.
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Kyeong et al. (2023) conducted an observational in Stroke (n=41,931). Self-calculation scoring model was evaluated on Area under the receiver operating curve (AUROC) for stroke prediction in the test dataset. A flexible self-calculation scoring model incorporating age, average glucose level, heart disease, and hypertension predicted stroke occurrence with an AUROC of 83.4% and 90.6% accuracy in the test dataset.
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