Key result
A self-calculation score using age, glucose, heart disease, and hypertension predicts stroke with ~83% AUROC.
Why the study?
Primary prevention of stroke requires identifying and managing determinants across various datasets, motivating the development of a flexible scoring model that can easily modify different datasets.
Can a flexible scoring model using age, average glucose level, heart disease, and hypertension predict stroke occurrence?
Observational (n=41,931)
Can a flexible scoring model using age, average glucose level, heart disease, and hypertension predict stroke occurrence?
A novel, flexible point scoring model using four determinants (age, average glucose level, heart disease, and hypertension) was developed to predict stroke occurrence, aiding in primary prevention.
May aid primary stroke prevention risk assessment; leaves open prospective validation before routine use.
Stroke has become a significant threat to global public health, the ideal solution to which is primary prevention. Identification and management of determinants of stroke among various variables in different datasets are essential steps for its primary prevention. This study aimed to develop a flexible scoring model, which can easily modify different datasets. The public dataset containing 41,931 cases with 643 occurrences of stroke was randomly divided into training, validation, and test datasets comprising 25,158 (60%), 8,386 (20%), and 8,387 (20%) cases, respectively. Three continuous variables (age, body mass index, and average glucose level) and seven categorical variables (heart disease, hypertension, sex, married/smoking/work/residence status) in the dataset were converted using the weight of evidence method. The significant variables among 10 transformed variables were selected using multivariable logistic regression analyses. The scoring model for stroke occurrence was developed in the training and validation datasets, and performance was evaluated in the test dataset. Age, average glucose level, heart disease, and hypertension were significant variables of stroke occurrence. The scoring model was easily calculated using four determinants and indicates that the stroke occurrence ranged from 0.04–12.50%. The performance of the scoring model on the test dataset was similar to that on the validation dataset. This novel point scoring model is flexible enough to modify various datasets and can be used for determinant identification. Furthermore, its simplicity allows individuals to manage determinants by self-calculating stroke occurrence. Our model contributes to primary prevention using determinant identification and management.
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Kyeong et al. (2022) conducted an observational in Stroke (n=41,931). Flexible self-calculation scoring model was evaluated on Model discriminatory power (AUROC) on the test dataset. A flexible self-calculation scoring model using age, average glucose level, heart disease, and hypertension predicted stroke occurrence with an AUROC of 83.4% in the test dataset.
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