Key result
Amiodarone-induced thyrotoxicosis in 3 patients on concomitant amiodarone and warfarin was heralded by a significant decrease in warfarin requirements.
Population
3 patients on concomitant amiodarone and warfarin who developed amiodarone-induced thyrotoxicosis
Design
Case_series
Authors
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Unexplained warfarin dose reductions on amiodarone may signal thyrotoxicosis; case reports leave open need for prospective confirmation.
Case Report (n=3)
Unexplained changes in warfarin dose requirements in patients taking amiodarone should prompt thyroid function testing due to complex drug-drug-disease interactions.
Kurnik et al. (2004) conducted a case report in Cardiac arrhythmias (n=3). Amiodarone and warfarin was evaluated. Amiodarone-induced thyrotoxicosis in 3 patients on concomitant amiodarone and warfarin was heralded by a significant decrease in warfarin requirements.
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