Answers are grounded in this paper and cite their sources.
Sub-freezing temperatures, azabenzotriazolide activation, multiple monomer addition, and helper displacement help to overcome what seemed like an intrinsic block of adenine-templated RNA replication steps in the absence of enzymes.
No takes yet. Share an insight, caveat, or question.
Vogel et al. (2007) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: