Race/Ethnicity, Income, Major Risk Factors, and Cardiovascular Disease Mortality
Key result
Black race was associated with higher cardiovascular disease mortality compared to White race, though this was largely mediated by risk factors and income (adjusted HR 1.05; 95% CI 1.01-1.10).
Why the study?
Does Black race/ethnicity compared to White race/ethnicity affect cardiovascular disease mortality across major risk factor levels in men aged 35 to 57 years?
Population
320,870 men aged 35 to 57 years who were screened for the Multiple Risk Factor Intervention Trial
Comparison
Black race/ethnicity vs White race/ethnicity
Design
Cohort
Follow-up
25 years
Authors
Discussion
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Member takes
Implication
Supports primordial prevention efforts; leaves open unmeasured social factors in racial CVD mortality differences.
Study Design
Type
Cohort (n=320,870)
Structured PICO
Does Black race/ethnicity compared to White race/ethnicity affect cardiovascular disease mortality across major risk factor levels in men aged 35 to 57 years?
P
Population
320,870 men (300,647 White and 20,223 Black) aged 35 to 57 years who were screened for the Multiple Risk Factor Intervention Trial (MRFIT)
I
Intervention
Black race/ethnicity
C
Comparator
White race/ethnicity
O
Outcome
Cardiovascular disease (CVD) mortalityhard clinical
Main Result
Effect estimate: HR 1.05 (95% CI 1.01-1.10)
Absolute Event Rate: 12.45% vs 10.24%
Higher CVD mortality rates among Black men compared to White men are largely mediated by differences in major risk factors and income, highlighting the need for primordial risk factor prevention.
Cite This Study
Thomas et al. (2005) conducted a cohort in Cardiovascular disease (n=320,870). Black race vs. White race was evaluated on Cardiovascular disease mortality (HR 1.05, 95% CI 1.01-1.10). Black race was associated with higher cardiovascular disease mortality compared to White race, though this was largely mediated by risk factors and income (adjusted HR 1.05; 95% CI 1.01-1.10).