Key result
COVID-19 linked to vasa vasorum vasculitis and microvascular thrombi in fatal ischemic stroke.
Why the study?
Patients with COVID-19 demonstrate higher rates of cardiovascular complications, which may be caused by progressive viral alteration of blood vessels, including vasa vasorum.
Case Report (n=1)
Autopsy findings suggest that SARS-CoV-2 may cause vasa vasorum vasculitis and microvascular thrombosis, potentially contributing to atherosclerotic plaque instability and cardiovascular complications.
Should not yet alter stroke care in COVID-19; hypothesis-generating for SARS-CoV-2 vasculopathy and needs confirmation.
Patients with COVID-19 demonstrate higher rates of cardiovascular complications, including thromboses and thromboembolism. One may suppose that the action of SARS-CoV-2 transforms stable atherosclerotic plaques into unstable status. Cardiovascular complications in COVID-19 may be caused by progressive viral alteration the blood vessels, including vasa vasorum. A lethal case of ischemic brain disease caused by cerebral atherosclerosis and exacerbated with a stroke during COVID-19 infection is briefly described. The results of autopsy showed perivascular lymphocytic infiltration and signs of vasa vasorum vasculitis with thrombi of adventitial microvasculature. The data discussed in the article are interpreted in context of the concept giving the important role in atherogenesis to vasa vasorum.
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Makarova et al. (2023) conducted a case report in COVID-19 and ischemic brain disease (n=1). COVID-19 infection in a lethal case of ischemic stroke was associated with autopsy findings of perivascular lymphocytic infiltration and vasa vasorum vasculitis with microvasculature thrombi.
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