The Discovery NM 530c solid-state cardiac camera demonstrated a 91.9% per-patient diagnostic agreement rate for detecting myocardial perfusion defects, comparable to the 92.5% agreement of standard dual-detector SPECT.
Observational (n=168)
Blinded readers
Yes
Does the Discovery NM 530c solid-state cardiac camera provide comparable diagnostic performance to standard dual-detector SPECT in patients referred for myocardial perfusion imaging?
The novel solid-state-detector cardiac camera provides comparable diagnostic performance to standard dual-detector SPECT for myocardial perfusion imaging, but with significantly shorter acquisition times and superior image quality.
Effect estimate: Difference -0.6% (95% CI -5.0% to 3.8%)
Absolute Event Rate: 91.9% vs 92.5%
p-value: p=0.99
OBJECTIVE: To compare the diagnostic performance of a new dedicated ultrafast solid-state cardiac camera (Discovery NM 530c DNM) with standard dual detector cameras (S-SPECT) in myocardial perfusion imaging. The primary goal was a per-patient analysis of diagnostic performance of the DNM using S-SPECT as the reference standard. METHODS AND RESULTS: In total, 168 patients underwent one-day Tc-99m tetrofosmin rest/stress myocardial perfusion SPECT. DNM and S-SPECT images were obtained with the same injected doses. The DNM camera uses an array of cadmium zinc telluride pixilated detectors and a multipinhole collimator simultaneously imaging all cardiac views with no moving parts. Rest and stress acquisition times were 4 and 2 minutes for DNM and 14 and 12 minutes for S-SPECT. Two blinded readers independently interpreted all scans on a patient level and on a vascular territory level using a standard five-point scale. Interobserver differences were resolved by a third observer. Agreement between DNM and S-SPECT for presence or absence of myocardial perfusion defects on a per-patient analysis was 91.9% and 92.5%, respectively. Correlation coefficients of rest and stress left ventricular ejection fractions were 0.87 (P < .01) and 0.90 (P < .01). CONCLUSION: The diagnostic performance of DNM is comparable to that of S-SPECT on a per-patient basis. However, superior image quality can be achieved with significantly shorter acquisition times with DNM because of improved count sensitivity and image contrast over S-SPECT.
Esteves et al. (Mon,) conducted a observational in Known or suspected coronary artery disease (n=168). Discovery NM 530c (DNM) solid-state cardiac camera vs. Standard dual-detector SPECT (S-SPECT) was evaluated on Per-patient agreement rate for presence or absence of stress perfusion defects (Difference -0.6%, 95% CI -5.0% to 3.8%, p=0.99). The Discovery NM 530c solid-state cardiac camera demonstrated a 91.9% per-patient diagnostic agreement rate for detecting myocardial perfusion defects, comparable to the 92.5% agreement of standard dual-detector SPECT.