Key result
A multi-frequency processing method using a wideband IVUS catheter (60 MHz and 25 MHz) was developed and demonstrated to enhance arterial lumen visualization in vitro and in an in vivo animal study.
A novel multi-frequency IVUS processing method improves arterial lumen visualization by differentiating scattering characteristics of blood and tissue.
May improve future IVUS lumen assessment; leaves open translation from animal models to clinical use.
The need to further improve the spatial resolution of intravascular ultrasound (IVUS) may drive the transducer center frequency even higher than the current 40 MHz range. Using a higher frequency results in stronger scattering echoes from the blood and may hamper visualization of the arterial lumen. This paper presents a multi-frequency processing method to enhance the arterial lumen by extracting the different scattering characteristics between blood and arterial tissues. A novel wideband catheter enables transmitting a broadband excitation pulse and processing signals in different frequency ranges, allowing detection of the signal ratio between the high (60 MHz) and low (25 MHz) frequencies. To evaluate this method, an in vitro experiment with porcine blood will be described. The lumen enhancement method will be demonstrated in vivo in an animal study.
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Li et al. (2008) studied Arterial lumen visualization. Multi-frequency processing with wideband IVUS (60 MHz and 25 MHz) was evaluated on Lumen enhancement. A multi-frequency processing method using a wideband IVUS catheter (60 MHz and 25 MHz) was developed and demonstrated to enhance arterial lumen visualization in vitro and in an in vivo animal study.
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