May 6, 1997Circulation
Prediction of Restenosis After Coronary Balloon Angioplasty
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Implication
Prospective study finds post-angioplasty ultrasound measurements fail to predict restenosis in coronary patients, indicating ultrasound cannot reliably forecast arterial re-narrowing.
Key Points
- Determine whether qualitative and quantitative intracoronary ultrasound (ICUS) parameters obtained after successful balloon angioplasty can identify lesions at high risk for 6-month restenosis.
- Recruited 200 patients who underwent ICUS imaging immediately following successful percutaneous transluminal coronary angioplasty (PTCA).
- Followed patients for 6 months to perform quantitative coronary angiography, successfully evaluating 164 patients (82%) with 170 target lesions.
- Categorical restenosis (≥50% diameter stenosis) occurred in 29.4% of evaluated lesions at the 6-month angiographic follow-up.
- Quantitative ICUS parameters weakly correlated with follow-up minimal luminal diameter (lumen area: R²=0.36, P=0.0001; vessel area: R²=0.29, P=0.0002; plaque area: R²=-0.18, P=0.021), but did not significantly associate with categorical restenosis (P=0.63, P=0.77, and P=0.38, respectively).
- Neither plaque morphology (eccentricity P=1.0; plaque composition P=0.98) nor vessel disruptions (rupture P=0.79; dissection P=0.31) significantly predicted restenosis.
Cite This Study
Peters et al. (1997) studied this question.