Key result
Aortic pulse wave velocity was significantly higher in patients with coronary artery disease (12.24 m/s) compared to healthy controls (8.27 m/s), and was further elevated in patients with in-stent restenosis (14.03 m/s).
Why the study?
Does arterial stiffness correlate with the presence of coronary artery disease and in-stent restenosis in patients undergoing coronary angiography?
Observational (n=219)
Single-blind (assessors)
No
Does arterial stiffness correlate with the presence of coronary artery disease and in-stent restenosis in patients undergoing coronary angiography?
Arterial stiffness is significantly elevated in patients with coronary artery disease and shows a strong correlation with in-stent restenosis and left main stenosis.
Answers are grounded in this paper and cite their sources.
Arterial stiffness assessment may aid CAD evaluation; leaves open whether PWV improves risk stratification in prospective studies.
BACKGROUND: Coronary artery disease (CAD) is one of the most important issues in modern medicine due to its high mortality and prevalence. An early detection and prevention can reduce morbidity and mortality. Arterial stiffness is a potent and independent predictor of CAD. We aimed to investigate the arterial stiffness in CAD patients undergoing the coronary angiography. Also, we investigated a possible correlation between arterial stiffness and in-stent restenosis (ISR), an important limitation of percutaneous coronary intervention (PCI). METHODS: The study included 160 patients undergoing coronary angiography, treated either with PCI or with CABG. The pulse wave velocity (PWV) and augmentation index (AIx) were measured by the Arteriograph. RESULTS: PWV in the CAD group (12.24 ± 2.78 m/s) was significantly higher compared to the control group (8.27 ± 1.89 m/s). PWV in ISR and left main (LM) stenosis group (14.03 ± 3.15 and 13.89 ± 2.95 m/s) was significantly higher compared to the control and CAD groups. Peripheral and central AIx were significantly higher in CAD group (1.38 ± 30.63 % and 38.35 ± 15.52 %) than in control group (-11.35 ± 26.74 % and 26.91 ± 10.62 %). Patients with LM stenosis have significantly higher values of peripheral and central AIx (23.37 ± 23.77 % and 49.71 ± 12.02 %) than the CAD and ISR group. CONCLUSIONS: The study confirmed a positive correlation between arterial stiffness measures, PWV and AIx, and CAD. Also, this study showed the correlation between PWV and ISR which can help to select more appropriate stent.
No takes yet. Share an insight, caveat, or question.
Prskalo et al. (2016) conducted an observational in Coronary artery disease and in-stent restenosis (n=219). Arterial stiffness measurement (Pulse Wave Velocity) vs. Healthy controls was evaluated on Aortic pulse wave velocity (PWV) in m/s (p=<0.05). Aortic pulse wave velocity was significantly higher in patients with coronary artery disease (12.24 m/s) compared to healthy controls (8.27 m/s), and was further elevated in patients with in-stent restenosis (14.03 m/s).
Synapse has enriched 10 related papers. Consider them for comparative context: