Key result
Kidney renin release is controlled by cAMP and Ca(2+) signaling pathways, with its biological actions mediated by receptors for (pro)renin, angiotensin II, and angiotensin-(1-7).
Design
Review
Authors
Loading...
Reinforces RAAS centrality in hypertension and HF; leaves open receptor-specific targeting for future trials.
This review outlines the physiological and molecular mechanisms of kidney renin production, storage, and release, which are central to the renin-angiotensin-aldosterone cascade.
Castrop et al. (2010) conducted a review in Physiology of Kidney Renin. Kidney renin release is controlled by cAMP and Ca(2+) signaling pathways, with its biological actions mediated by receptors for (pro)renin, angiotensin II, and angiotensin-(1-7).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: