Key result
A single 50-mg dose of sildenafil significantly increased the high-frequency component and decreased the low/high-frequency ratio of heart rate variability during slow wave sleep compared to placebo.
Why the study?
Does a single 50-mg dose of sildenafil alter heart rate variability during sleep in male patients with severe obstructive sleep apnea?
Population
13 male patients with severe obstructive sleep apnea (mean age 43+/-10 years, mean BMI 26.7+/-1.9 kg/m2)
Comparison
Single 50-mg dose of sildenafil at bedtime vs Placebo at bedtime
Follow-up
One night
Authors
Loading...
May prompt caution with sildenafil in severe OSA; extends evidence of acute PDE5i autonomic effects to sleep.
RCT (n=13)
Double-blind
Randomized
No
Does a single 50-mg dose of sildenafil alter heart rate variability during sleep in male patients with severe obstructive sleep apnea?
Absolute Event Rate: 0.28% vs 0.12%
p-value: p=0.0001
A single dose of sildenafil alters autonomic nervous function during sleep in patients with severe obstructive sleep apnea, suggesting potential immediate cardiac effects.
Neves et al. (2010) conducted an RCT in Severe obstructive sleep apnea (n=13). Sildenafil vs. Placebo was evaluated on High-frequency (HF) component of heart rate variability during slow wave sleep (p=0.0001). A single 50-mg dose of sildenafil significantly increased the high-frequency component and decreased the low/high-frequency ratio of heart rate variability during slow wave sleep compared to placebo.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: