Key result
Sequential amiodarone and dronedarone for AF linked to permanent bilateral vision loss from optic neuropathy.
Why the study?
Amiodarone and dronedarone have recognized ophthalmological adverse effects including optic neuropathy, and timely recognition may enable drug withdrawal to prevent permanent vision loss.
Case Report (n=1)
Highlights the importance of timely recognition of optic neuropathy as a complication of amiodarone and dronedarone treatment to prevent permanent vision loss.
Clinicians should consider optic neuropathy risk with amiodarone or dronedarone; case report leaves causality open.
SIGNIFICANCE: Amiodarone and dronedarone have recognized ophthalmological adverse effects including optic neuropathy. The recognition of optic neuropathy as a complication of amiodarone and dronedarone treatment may enable withdrawing the drug and accordingly preventing permanent vision loss. PURPOSE: This study aimed to describe a case of optic neuropathy after substitution of amiodarone with dronedarone for treatment of atrial fibrillation. CASE REPORT: An 81-year-old man treated with dronedarone for atrial fibrillation after amiodarone had caused tremor developed sequential permanent vision loss in both eyes. CONCLUSIONS: The importance of timely recognition of optic neuropathy as a complication of amiodarone and dronedarone treatment may enable discontinuing the drug, thus preventing permanent vision loss.
No takes yet. Share an insight, caveat, or question.
Maharshak et al. (2020) conducted a case report in Atrial fibrillation (n=1). Amiodarone and Dronedarone was evaluated on Sequential permanent vision loss (optic neuropathy). Treatment with amiodarone and subsequently dronedarone for atrial fibrillation in an 81-year-old man resulted in sequential permanent vision loss in both eyes due to presumed optic neuropathy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: