March 1, 1992Pacing and Clinical Electrophysiology
Results of Electrophysiological Testing and Long‐Term Follow‐Up in Patients Sustaining Cardiac Arrest Only While Receiving Type IA Antiarrhythmic Agents
Key result
Electrophysiological testing in patients with cardiac arrest on type Ia agents showed 66% had inducible arrhythmias, with 13 of 29 patients experiencing sudden death or ICD shock over 28 months.
Why the study?
Does electrophysiological testing predict the risk of recurrent ventricular tachyarrhythmias in patients sustaining cardiac arrest only while receiving type IA antiarrhythmic agents?
Population
29 patients with no prior history of sustained ventricular tachyarrhythmias who suffered a cardiac arrest…
Design
Cohort
Follow-up
mean 28 +/- 27 months (range: 1 day-84 months)
Authors
Discussion
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Member takes
Implication
High recurrent event rates occur regardless of EP inducibility; leaves open whether testing stratifies risk in type Ia-associated arrest.
Study Design
Type
Observational (n=29)
Structured PICO
Does electrophysiological testing predict the risk of recurrent ventricular tachyarrhythmias in patients sustaining cardiac arrest only while receiving type IA antiarrhythmic agents?
P
Population
29 patients (mean age 61 +/- 9 years) with no prior history of sustained ventricular tachyarrhythmias who suffered a cardiac arrest only while receiving type Ia antiarrhythmic agents. Excluded: documented myocardial infarction, acute ischemia, electrolyte abnormalities, or torsade de pointes.
I
Intervention
Electrophysiological testing (baseline and rechallenge with procainamide or quinidine) followed by guided or empirical therapy (antiarrhythmic agents, subendocardial resection, or implantable cardioverter defibrillator)
O
Outcome
Sudden death or defibrillator shock preceded by syncope or presyncopehard clinical
Patients sustaining cardiac arrest while on type IA antiarrhythmic agents remain at high risk for recurrent ventricular arrhythmias regardless of their inducibility during electrophysiological testing.
Cite This Study
Hook et al. (1992) conducted an observational in Cardiac arrest while receiving type Ia antiarrhythmic agents (n=29). Electrophysiological testing was evaluated on Sudden death or defibrillator shock preceded by syncope or presyncope. Electrophysiological testing in patients with cardiac arrest on type Ia agents showed 66% had inducible arrhythmias, with 13 of 29 patients experiencing sudden death or ICD shock over 28 months.