Experimental study demonstrates peptide sequencing using metastable ion decay in reflection time-of-flight mass spectrometry, indicating a practical strategy for structural analysis of large peptides.
A novel method of peptide sequencing by mass spectrometry is described. Metastable decay of laser-desorbed ions, taking place in the first field-free drift region of a reflection time-of-flight mass spectrometer, has been monitored to get structural information from larger peptides. Fragment ions from metastable decay are mass analysed by adjusting the potentials of the ion reflectron according to the kinetic energies of the ions. The features of the technique and its significance for future applications are outlined.
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Spengler et al. (1992) studied this question.
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