Key result
A heterogeneous formulation of the Himeno et al. ventricular myocyte model reproduced the inverse relationship between extracellular calcium and action potential duration, matching clinical QT changes.
A novel heterogeneous human ventricular myocyte model successfully simulates physiological ventricular ECGs and accurately reflects QT prolongation under hypocalcaemic conditions.
Should not yet alter calcium management; extends heterogeneous myocyte models to match clinical QT dynamics.
at the apex by a factor of 3.5 compared to the base to obtain an APD shortening of 12.5%. The setup comprising transmural and apico-basal heterogeneity yielded a physiological ventricular ECG. Our novel setup allows to study, for the first time, how realistic changes of the AP under hypo-and hypercalcaemic conditions translate to changes in the ECG. Resulting QT prolongation under hypocalcaemic conditions matched human experimental data.
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Loewe et al. (2018) studied Hypocalcaemia and hypercalcaemia. Heterogeneous Himeno et al. human ventricular myocyte model vs. Homogeneous setup was evaluated on Action potential duration and QT interval changes. A heterogeneous formulation of the Himeno et al. ventricular myocyte model reproduced the inverse relationship between extracellular calcium and action potential duration, matching clinical QT changes.
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