Key result
A combination of transmural (with M cells on the endocardial side) and moderate apicobasal gradients in action potential duration was required to produce physiological T waves in a simulated surface ECG.
Computational modeling demonstrates that physiological T-wave morphology on the surface ECG requires a combination of transmural and moderate apicobasal repolarization gradients.
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T-wave genesis models may refine ECG repolarization analysis; leaves open validation and clinical translation in humans.
Okada et al. (2011) studied T-wave morphology. Transmural and apicobasal gradients in repolarization was evaluated on T-wave morphology in surface ECG. A combination of transmural (with M cells on the endocardial side) and moderate apicobasal gradients in action potential duration was required to produce physiological T waves in a simulated surface ECG.
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