Key result
Experimental manipulation of murine transmural gradients by shortening epicardial MAP90 to 84% of endocardial MAP90 resulted in a positive murine T wave.
Why the study?
Does manipulation of transmural action potential durations affect T wave morphology in murine hearts?
Population
Murine hearts (in vivo model)
Comparison
Experimental manipulation of murine transmural… vs Unmanipulated murine hearts
Design
Preclinical
Authors
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Murine T-wave polarity can be reversed by gradient manipulation; hypothesis-generating for repolarization mechanisms across species.
Does manipulation of transmural action potential durations affect T wave morphology in murine hearts?
Manipulating transmural gradients in murine hearts to mimic larger mammals can produce a positive T wave, elucidating the determinants of murine T wave morphology.
Liu et al. (2003) studied Murine electrophysiology. Manipulation of transmural action potential durations was evaluated on T wave morphology. Experimental manipulation of murine transmural gradients by shortening epicardial MAP90 to 84% of endocardial MAP90 resulted in a positive murine T wave.
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