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May 24, 2026JHEP ReportsOpen Access

Prognostic Significance of Pretreatment 18F-FDG PET/CT in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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Authors

JMJi Hye MinMRMohammad Saeid Rezaee-ZavarehAAAbdelrahman M. Attia

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Overview

Systematic review and meta-analysis reveals higher FDG uptake correlates with worse outcomes in HCC, suggesting further investigation is needed.

Key Points

  • This research aims to assess the prognostic significance of pretreatment 18F-FDG PET/CT in hepatocellular carcinoma (HCC).
  • Conducted a systematic review and meta-analysis.
  • Evaluated various PET/CT parameters including SUVmax and tumor-to-liver ratio.
  • Assessed associations between FDG uptake and clinical outcomes.
  • Higher FDG uptake indicated poorer clinical outcomes across therapy modalities.
  • PET/CT parameters demonstrated consistent prognostic value.
  • Recommendation for further investigation into FDG PET/CT for patient selection.

Cite This Study

Min et al. (2026) studied this question.

synapsesocial.com/papers/6a12949848a0ea166567103chttps://doi.org/10.1016/j.jhepr.2026.101901
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dual-tracer [18F]F-FDG and [18F]F-FAPI-04 PET/CT for predicting tumor aggressiveness and prognosis in hepatocellular carcinoma2026
  2. 2Prognostic Value of 18F-FDG and 18F-FEC Uptake in Hepatocellular Carcinoma Using Contrast-Enhanced Integrated PET/MRI: Correlation with Histology and Survival2026
  3. 3High standard uptake value on FDG-PET/CT of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection2024
  4. 468Ga-FAPI-04 PET/CT in the Diagnosis of Hepatocellular Carcinoma Associated with Cirrhosis: Diagnostic Value, Correlation Between PET Parameters of the Tumor and Its Size, and PIVKA-II Levels2026 · 1 citations
  5. 5High standard uptake value of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection2024