Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study

Carla Daniele Nascimento Pontes; Fernando G. Zampieri; Rodrigo C. Figueiredo; Rodolpho Augusto de Mouro Pedro; Luíz Marcelo Sá Malbouisson; Rodrigo Camillo da Cunha; Fernando José da Silva Ramos; Lucas Petri Damiani; Bruno Adler Maccagnan Pinheiro Besen; Flávio Geraldo Rezende de Freitas; Flávia Ribeiro Machado

doi:10.62675/2965-2774.20260300

January 1, 2026Critical Care ScienceOpen Access

Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study

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Key Points

To determine if methylene blue can effectively reduce hypotension during renal replacement therapy compared to usual care.
Randomized, multicenter, open-label trial
Participants are patients at high risk for hypotension during renal replacement therapy
Results regarding the effect of methylene blue on hypotension will be reported following data collection.

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Implication

Randomized trial evaluates methylene blue's impact on hypotension in high-risk patients during renal replacement therapy, suggesting potential benefits.

Abstract

Objective: To describe the study protocol and statistical analysis plan that will be used to evaluate whether methylene blue reduces interventions aimed at controlling hypotension during renal replacement therapy as compared to usual care. Methods: BLUE is a randomized, multicenter, open-label trial. Patients with high risk of hypotension during renal replacement therapy will be […]

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Pontes et al. (2026) studied this question.

synapsesocial.com/papers/6a12950b48a0ea16656713d6 https://doi.org/10.62675/2965-2774.20260300

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Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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