Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 24, 2026Respiratory ResearchOpen Access

S100A9 deletion ameliorates acute lung injury by attenuating excessive neutrophil activation via activating the NRF2/HO-1 signaling axis

View Full Paper
Ask AI
Bookmark
Share

Authors

SYShuang YinAnhui Medical UniversityXHXinyu HuAnhui Medical UniversityHCHao CaiAnhui Medical University

Discussion

Loading...

Member takes

Overview

Randomized trial shows S100A9 deletion reduces neutrophil activation in lung injury, suggesting a therapeutic approach.

Key Points

  • This research investigates the effects of S100A9 deletion on LPS-induced acute lung injury and neutrophil activation.
  • Established a lung injury model using LPS in wild-type and S100A9 knockout mice.
  • Evaluated lung injury severity, inflammation, oxidative stress, and neutrophil characteristics both in vivo and in vitro.
  • Assessed survival rates and the activation of NRF2 signaling pathway.
  • S100A9 knockout significantly improved lung tissue injury and edema, reducing inflammatory cell infiltration.
  • Increased survival rates were observed in S100A9 KO mice compared to wild-type controls.
  • Activation of the NRF2 signaling pathway was identified as a mechanism that reduces neutrophil activation and NET production.

Cite This Study

Yin et al. (2026) studied this question.

synapsesocial.com/papers/6a12950b48a0ea1665671420https://doi.org/10.1186/s12931-026-03675-6
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pneumocystis murina promotes inflammasome formation and NETosis during Pneumocystis pneumonia2024 · 15 citations
  2. 2The Role of the Interleukin-17 Axis and Neutrophils in the Pathogenesis of Endemic and Systemic Mycoses2020 · 53 citations
  3. 3Linking oxidative stress biomarkers to disease progression and antioxidant therapy in hypertension and diabetes mellitus2025 · 45 citations
  4. 4Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-192021 · 16 citations
  5. 5S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway2025 · 17 citations