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May 24, 2026Journal of Managed Care & Specialty Pharmacy

Real-world use of semaglutide for obesity treatment: A cohort study in an integrated health care delivery system

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Authors

ABAngela BaalmannHigh Point UniversityJMJakub MichelHigh Point UniversitySASean N. AvedissianNebraska Medical Center

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Implication

Cohort study evaluates persistence and adherence to semaglutide, impacting weight loss in patients.

Key Points

  • Evaluate real-world persistence and adherence to semaglutide for obesity treatment and its impact on weight loss.
  • Retrospective cohort study from a single health system (2021-2024)
  • Analyzed prescription and clinical data for 393 patients
  • Used multivariable logistic regression to identify factors associated with persistence and adherence
  • 44% of patients remained persistent, losing a mean of 13.8% of baseline weight
  • 44% were adherent, experiencing 13% weight loss, with those on approved titration losing 12.5%
  • Female sex associated with lower odds of persistence (OR=0.32, 95% CI=0.14-0.75) and adherence (OR=0.33, 95% CI=0.14-0.77)

Cite This Study

Baalmann et al. (2026) studied this question.

synapsesocial.com/papers/6a12950b48a0ea1665671424https://doi.org/10.18553/jmcp.2026.32.6.660
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Persistence of Hormonal Adaptations to Weight Loss2011 · 1,446 citations
  2. 2Real-world persistence and adherence to glucagon-like peptide-1 receptor agonists among obese commercially insured adults without diabetes2024 · 170 citations
  3. 3Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity2019 · 2,054 citations
  4. 4Once-Weekly Semaglutide in Adults with Overweight or Obesity2021 · 5,106 citations
  5. 5Direct medical costs of obesity in the United States and the most populous states2021 · 408 citations