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May 21, 2026International Journal of Molecular MedicineOpen Access

CTRP3 alleviates neuropathic pain by improving mitochondrial biogenesis and mitochondrial unfolded protein response via spinal SIRT1 in rats

Tianzhu Liu Longqing Zhang Wei Mei

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Key Points

The aim is to explore how CTRP3 affects neuropathic pain mechanisms through mitochondrial pathways.
Evaluated the impact of CTRP3 on neuropathic pain in a rat model.
Investigated mitochondrial biogenesis and unfolded protein response through spinal SIRT1.
Utilized biochemical and behavioral assessments to measure pain responses.
CTRP3 treatment significantly improved mitochondrial function and reduced pain behaviors.
Enhanced SIRT1 activity was observed alongside increased mitochondrial biogenesis.
CTRP3 demonstrated potential as a therapeutic target for managing neuropathic pain.

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Implication

Evaluates CTRP3's effect on neuropathic pain, suggesting a new treatment approach.

Abstract

. CTRP3 may therefore represent a novel therapeutic target for the management of neuropathic pain.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a12950b48a0ea166567146f https://doi.org/10.3892/ijmm.2026.5868

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