Preoperative Assessment of Peritoneal Carcinomatosis with [ ⁶⁸ Ga]Ga-FAPI-46 PET/CT: Agreement with Surgicopathologic PCI and Comparison with MRI and [ ¹⁸ F]FDG PET/CT

Ayça Arçay Öztürk; Gabriel Liberale; Anne-Leen Deleu; Raluca Poenaru; Erwin Woff; Ana Verón Sánchez; Laurine Verset; Laura Polastro; Jean-Christophe Noël; Paulus Kristanto; Sigrid Vercauteren; Clémentine Marin; Zéna Wimana; Mutaz Kassas; Loubna Taraji; Patrick Flamen

doi:10.2967/jnumed.126.272183

May 21, 2026Journal of Nuclear Medicine

Preoperative Assessment of Peritoneal Carcinomatosis with [ ⁶⁸ Ga]Ga-FAPI-46 PET/CT: Agreement with Surgicopathologic PCI and Comparison with MRI and [ ¹⁸ F]FDG PET/CT

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Key Points

This research aims to evaluate the effectiveness of FAPI PET in assessing peritoneal carcinomatosis compared to traditional imaging techniques.
Evaluated preoperative assessment using FAPI PET/CT and compared it with MRI and FDG PET/CT.
Measured agreement with surgical-pathological peritoneal carcinomatosis index (PCI).
Assessed imaging performance post-chemotherapy.
FAPI PET showed the strongest agreement with surgicopathologic PCI.
Detectability of peritoneal carcinomatosis was higher with FAPI PET than with MRI and FDG PET.
Performance of FAPI PET remained preserved even after chemotherapy.

Implication

Demonstrates improved detection of peritoneal carcinomatosis in patients, suggesting enhanced preoperative mapping.

Abstract

FAPI PET demonstrated the strongest overall agreement with surgicopathologic PCI and higher detectability than MRI with diffusion-weighted imaging and FDG PET, with preserved performance after chemotherapy, supporting its role for preoperative PC mapping.

Discussion

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Cite This Study

Öztürk et al. (2026) studied this question.

synapsesocial.com/papers/6a12953848a0ea166567151b https://doi.org/10.2967/jnumed.126.272183

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Preoperative Assessment of Peritoneal Carcinomatosis with [ ⁶⁸ Ga]Ga-FAPI-46 PET/CT: Agreement with Surgicopathologic PCI and Comparison with MRI and [ ¹⁸ F]FDG PET/CT

Key Points

Implication

Abstract

Discussion

Cite This Study

Preoperative Assessment of Peritoneal Carcinomatosis with [ ⁶⁸ Ga]Ga-FAPI-46 PET/CT: Agreement with Surgicopathologic PCI and Comparison with MRI and [ ¹⁸ F]FDG PET/CT

Key Points

Implication

Abstract

Discussion

Cite This Study

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