What question did this study set out to answer?

To explore the link between metabolic acidosis and clinical outcomes in very low birth weight infants in South Korea.

Association between base excess levels and clinical outcomes among very low birth weight infants: a multicenter birth cohort study in South Korea

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Multicenter trial investigates metabolic acidosis impact on clinical outcomes of very low birth weight infants, indicating significant associations.

To explore the link between metabolic acidosis and clinical outcomes in very low birth weight infants in South Korea.
Data collected from the Korean Neonatal Network across 75 hospitals (2013-2019)
Cohort included 14,519 infants <1,500 g in neonatal intensive care
Blood gas measurements assessed clinical outcomes based on base excess levels.
BE level < -9 linked to high risks of respiratory outcomes including air leak syndrome (aOR, 2.071; 95% CI, 1.305-3.285)
Significant risks for neurological (aOR, 2.797; 95% CI, 2.314-3.380) and mortality outcomes (aOR, 2.683; 95% CI, 2.076-3.466) were also noted.

Kim et al. (2026) studied this question.

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Multicenter trial investigates metabolic acidosis impact on clinical outcomes of very low birth weight infants, indicating significant associations.