Randomized trial reveals IL-33 release contributes to eosinophilia in mice sensitized via SDS-treated skin, indicating a novel mechanism.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1. Supplementary methods. Figure S1. Airway inflammation induced by papain challenge is independent of the protease activity of papain used during the epicutaneous sensitization phase. Figure S2. Protease activity during the airway challenge phase contributes partially or not at all to airway inflammation in mice sensitized via SDS-treated skin. Figure S3. Supporting Information supporting the role of protease-independent, Th cell-dependent IL-33 release in airway eosinophilia. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Takada et al. (2026) studied this question.
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