Beyond Circulating Tumor DNA for Efficacy: Can We Use Cell-Free DNA to Detect and Monitor Toxicity Signals?

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to explore the potential of cell-free DNA (cfDNA) in detecting and monitoring toxicity signals using biomarkers.
Utilized cell type methylome atlases to identify differentially methylated regions (DMRs),
Analyzed unmethylated regions overlapping cell type-specific enhancers as biomarkers for cfDNA quantification.
Investigated the universality of developmentally linked loci across individuals of varying age, sex, and ethnicity.
Identified thousands of DMRs, with 97% being unmethylated and potentially useful as biomarkers.
Confirmed that developmentally linked loci are consistent across diverse individual demographics.
Demonstrated the feasibility of using cfDNA for toxicity monitoring.

Answers are grounded in this paper and cite their sources.

Examines cell-free DNA as a biomarker for detecting toxicity in diverse populations, suggesting its universal application.

No abstract yet. The journal hasn't published one we can show.

No takes yet. Share an insight, caveat, or question.

Zhao et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Share