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This report aims to highlight the risk of encephalopathy from valacyclovir in frail older adults within geriatric healthcare.

Valacyclovir‐Induced Encephalopathy in a Frail Oldest‐Old Resident of a Geriatric Health Services Facility: Implications for Safety‐First Antiviral Dosing

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This report aims to highlight the risk of encephalopathy from valacyclovir in frail older adults within geriatric healthcare.
Case report of a frail oldest-old resident experiencing symptoms after valacyclovir administration.
Clinical observations and assessments conducted to determine the cause of symptoms.
The patient exhibited acute neurological symptoms linked to valacyclovir use.
Findings suggest the need for careful dosing of antivirals in vulnerable populations.

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Case report shows valacyclovir-induced encephalopathy in frail older adults, highlighting safety considerations in antiviral dosing.

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Tsuda et al. (2026) studied this question.

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