Advances in Nanozyme Engineering for Precision Oral Health Management

INTRODUCTION AND AIMS: Despite recent advances in dental care, traditional treatments suffer from poor targeting, limited stability, and unsatisfactory regenerative efficacy. This review aims to clarify the multi-level intervention targets of nanozymes for oral diseases, highlight their unique merits over conventional strategies, and provide a theoretical basis for developing novel precision oral therapeutic systems. METHODS: High-quality literature was retrieved from PubMed, Web of Science, and other core databases, including in vitro, in vivo, and emerging clinical studies on the design, function, and applications of nanozymes in oral diseases. CONCLUSIONS: Nanozymes demonstrate significant potential for targeted antibacterial therapy, oxidative stress regulation, and tissue repair within the complex oral microenvironment. Their integration with advanced delivery platforms enhances therapeutic precision. Future development should focus on multi-enzyme synergistic systems, improved biocompatibility, and clinical translation to realize their promise in precision oral medicine. CLINICAL SIGNIFICANCE: Nanozymes represent a paradigm shift from passive to active, dynamic oral therapeutics. They offer a promising strategy for managing biofilm-associated diseases (caries, periodontitis) and complex conditions (oral mucositis, cancer) with enhanced specificity and regenerative potential, potentially reducing antibiotic reliance and improving long-term treatment outcomes.