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May 24, 2026Chemical Reviews

Metal-Catalyzed Reductive Coupling of Aryl Halides beyond Premetalated Reagents or Metallic Reductants: Biaryl Formation

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Authors

YCYoon ChoThe University of Texas at AustinYCYu-Hsiang ChangThe University of Texas at AustinWSWeijia ShenThe University of Texas at Austin

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Overview

Monograph surveys metal-catalyzed reductive couplings for biaryl formation, suggesting new methodology.

Key Points

  • To explore alternative methods for biaryl formation through aryl halide reductive couplings without relying on premetalated reagents.
  • Survey of metal-catalyzed reductive homocouplings and cross-couplings
  • Focus on Ullmann reactions and nonmetallic reductants
  • Discussion of traditional palladium-catalyzed methods
  • Identified limitations of traditional palladium-catalyzed cross-couplings due to reliance on premetalated reagents.
  • Reviewed advances in direct catalytic aryl halide reductive couplings.
  • Highlighted the potential of nonmetallic reductants in biaryl synthesis.

Cite This Study

Cho et al. (2026) studied this question.

synapsesocial.com/papers/6a12955d48a0ea166567188chttps://doi.org/10.1021/acs.chemrev.5c00996
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